Scotland Yard confirmed police were called at 10.59pm (GMT).
No details have yet emerged on the victim’s condition.
A man was arrested at the scene on suspicion of GBH.
A crime scene remains in place at the north London location at the time of writing.
A Metropolitan police spokesman said: “A man was arrested at the scene on suspicion of GBH. A crime scene is in place. Enquiries continue.”
The callous attack is the fourth reported stabbing in London on Wednesday, November 7.
Other male victims were stabbed in Shepherds Bush, Hackney and another in Leytonstone.
Enfield has seen a wave of violent crime over the past year.
At the end of last month, a man believed to be in his 30s was found with multiple stab wounds to his leg.
The victim was rushed to hospital where his non-life threatening injuries were treated.
In March, Russell Jones, 23, died after suffering from stab injuries and a gunshot wound in Enfield, north London.
Ishak Tacine, 20, of Enfield, was repeatedly stabbed in Edmonton following reports of an altercation between men armed with baseball bats.
Tuesday, November 7, a 98-year-old victim suffered a head injury and multiple bruises in the “brutal and senseless” assault and robbery, police said.
READ MORE: Man stabbed to death in London
Officers were called to his home in Evesham Road, Enfield, just after 10am on Tuesday.
He was rushed to hospital where he remains in critical condition.
On Monday, the Mayor of London, Sadiq Khan, warned it could take a generation to turn the tide of violent crime in the capital.
He said: “To really make significant progress can take up to 10 years.”
READ MORE: Shaun Bailey attacks Sadiq Khan
Low levels of police on the beat has been partially blamed for the scourge in violence.
According to City Hall figures police coverage in London is at its lowest rate in 20 years with 3.3 police officers for every thousand Londoners – the lowest rate since 1998 and 19 percent below 2010.
Local leaders need to be more successful in lobbying the government for extra money for policing, Mr Khan said.